Fig. 3. LSD-induced reorganisation of functional connectivity in the predominantly segregated dynamic sub-state. Center: brain networks of significant functional connectivity differences (r values) between placebo and LSD, obtained from the Network Based Statistic with an intensity-based F-threshold of 10; Red-yellow indicates LSD > placebo; blue-green indicates LSD < placebo. Sides: surface projection of the total change in connectivity (sum of significant connection changes) for each region of the augmented Schaefer-232 atlas.

Hyper-connectivity of brain areas induced by DMT versus placebo overlap with evolved brain regions linked to human-specific evolved functions such as language and semantics.